Advancing the evidence base for off-label medications in children

A multicentre prospective audit with an embedded pharmacokinetic and pharmacodynamic study to determine the dosing regimens, safety and efficacy of off-label medications used in children.

BEST Trial

The BEST trial (Bone and Joint infection – Simplifying treatment in Children)

The BEST trial aims to determine whether treatment of bone and joint infections in children with oral antibiotics alone is just as effective as treatment with intravenous antibiotics followed by an oral antibiotic course.

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